Venice is one of the most interesting and lovely places in the world. This sanctuary on a lagoon is virtually the same as it was six hundred years ago, which adds to the fascinating character. Venice has decayed since its heyday and is heavily touristed (there are slightly more tourists than residents), but the romantic charm remains.
This place may not seem huge but it is. Venice is made of different boroughs. The most famous is the area comprising the 118 islands in the main districts that are called "Sestieri" and they are: Cannaregio, Castello, Dorsoduro, San Polo, Santa Croce and San Marco, where the main monuments and sights are located. Other main districts are Isola Della Giudecca and Lido di Venezia. Other important islands include Murano, Torcello, San Francesco del Deserto and Burano, but there are several.
The summer may be the worst time to visit: it's sometimes very hot and often humid, the canals usually smell, there are mosquitoes and occasional infestations of flies, and there are more tourists than usual. Spring and fall are probably best, a compromise between temperature (expect 5-15°C in March) and the tourist load. Between November and January, you may manage to feel you have Venice all to yourself, an interesting and quiet experience. Beware of the weather during the winter months: it can be quite cold, windy, and damp. Fog is an additional hazard if you are driving in or out, doubly so in the unlikely chance that you will pilot a boat. That said, if you've never been to Venice, it's better to go in summer than not to go. You won't regret it. Many cities are far worse in summer, and Venice has no cars, hence no smog.
Because Venice is on a lagoon, the water plays a crucial role in transportation. Whichever way you arrive, the last part of your journey will be on foot from the nearest waterbus/watertaxi jetty. If you need to carry or wheel bags along the narrow streets, bear this in mind when chosing your hotel location and route to it.